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  <xs:element id="tlsi_ClassOfWarrantOrRightOutstandingWarrantsIssuedDuringPeriodNewIssues" abstract="false" name="ClassOfWarrantOrRightOutstandingWarrantsIssuedDuringPeriodNewIssues" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_SharePriceAsPercentageOfMarketPriceWithAdvanceNoticeOptionTwo" abstract="false" name="SharePriceAsPercentageOfMarketPriceWithAdvanceNoticeOptionTwo" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_SeriesA1ConvertiblePreferredStockMember" abstract="true" name="SeriesA1ConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentContingentConsiderationLiabilityShares" abstract="false" name="DerivativeInstrumentContingentConsiderationLiabilityShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="tlsi_DerivativeFinancialInstrumentsSeriesB3WarrantLiabilityMember" abstract="true" name="DerivativeFinancialInstrumentsSeriesB3WarrantLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightThresholdNumberOfDaysForWarrantsToBeTransferable" abstract="false" name="ClassOfWarrantOrRightThresholdNumberOfDaysForWarrantsToBeTransferable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_GuidelinePublicCompanyModelMember" abstract="true" name="GuidelinePublicCompanyModelMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_MTACWarrantsMember" abstract="true" name="MTACWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_TrancheAxis" abstract="true" name="TrancheAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_ReverseRecapitalizationAbstract" abstract="true" name="ReverseRecapitalizationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_NatureOfBusinessTable" abstract="true" name="NatureOfBusinessTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_ProceedsFromReverseRecapitalizationTransaction" abstract="false" name="ProceedsFromReverseRecapitalizationTransaction" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_CommonStockSharePriceMarketPriceNumberOfConsecutiveTradingDays" abstract="false" name="CommonStockSharePriceMarketPriceNumberOfConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_RecapitalizationExchangeRatio" abstract="false" name="RecapitalizationExchangeRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightDaysFromWhichWarrantOrRightsBecomeExercisable" abstract="false" name="ClassOfWarrantOrRightDaysFromWhichWarrantOrRightsBecomeExercisable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_SeriesBConvertiblePreferredStockMember" abstract="true" name="SeriesBConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePerYearNumberOfYears" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePerYearNumberOfYears" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodThresholdTradingDays" abstract="false" name="DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodThresholdTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_CommercialMilestoneMember" abstract="true" name="CommercialMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_MeasurementInputExerciseSharePriceMember" abstract="true" name="MeasurementInputExerciseSharePriceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePerYearPercentageOfTotalStock" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePerYearPercentageOfTotalStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_SeriesA2ConvertiblePreferredStockMember" abstract="true" name="SeriesA2ConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_SeriesA5ConvertiblePreferredStockMember" abstract="true" name="SeriesA5ConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PaymentsForAssetsAcquisitionMilestone" abstract="false" name="PaymentsForAssetsAcquisitionMilestone" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_AssetAcquisitionNumberOfCommercialMilestones" abstract="false" name="AssetAcquisitionNumberOfCommercialMilestones" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_MeasurementInputFairValueSharePriceMember" abstract="true" name="MeasurementInputFairValueSharePriceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_CommercialMilestoneTypeAxis" abstract="true" name="CommercialMilestoneTypeAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodStockPriceTrigger" abstract="false" name="DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodStockPriceTrigger" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tlsi_StockConvertedReverseRecapitalization" abstract="false" name="StockConvertedReverseRecapitalization" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodVestingPercentage" abstract="false" name="DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodVestingPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_LeaseLiabilityCurrent" abstract="false" name="LeaseLiabilityCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentPeriodTwoMember" abstract="true" name="DerivativeInstrumentPeriodTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_LeaseLiabilityNoncurrent" abstract="false" name="LeaseLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_CommercialMilestone500000AnnualSalesMember" abstract="true" name="CommercialMilestone500000AnnualSalesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_NumberOfProductLinesInDevelopment" abstract="false" name="NumberOfProductLinesInDevelopment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_GainLossOnMilestonePaymentForAssetAcquistion" abstract="false" name="GainLossOnMilestonePaymentForAssetAcquistion" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_IncomeLossFromPreferredStockConvertibleDownRoundFeaturePerBasicShare" abstract="false" name="IncomeLossFromPreferredStockConvertibleDownRoundFeaturePerBasicShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tlsi_TrancheThreeMember" abstract="true" name="TrancheThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightConversionStockPriceThreshold" abstract="false" name="ClassOfWarrantOrRightConversionStockPriceThreshold" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tlsi_TrancheAndWarrantLiabilityMember" abstract="true" name="TrancheAndWarrantLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PaymentsForAssetAcquisitionMilestoneAmount" abstract="false" name="PaymentsForAssetAcquisitionMilestoneAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_DynavaxTechnologiesMember" abstract="true" name="DynavaxTechnologiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_SeriesB2ConvertiblePreferredStockMember" abstract="true" name="SeriesB2ConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightNumberOfWarrantsRepurchased" abstract="false" name="ClassOfWarrantOrRightNumberOfWarrantsRepurchased" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_ReverseRecapitalizationTransactionCostsPaid" abstract="false" name="ReverseRecapitalizationTransactionCostsPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_BinomialTrancheModelMember" abstract="true" name="BinomialTrancheModelMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_AssetAcquisitionRoyaltyPercentageUnderThresholdAmount" abstract="false" name="AssetAcquisitionRoyaltyPercentageUnderThresholdAmount" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
</xs:schema>
