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  <xs:element id="tlsi_DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodThresholdConsecutiveTradingDays" abstract="false" name="DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodThresholdConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodVestingPercentage" abstract="false" name="DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodVestingPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodStockPriceTrigger" abstract="false" name="DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodStockPriceTrigger" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tlsi_PublicWarrantsPrivatePlacementWarrantsAndWorkingCapitalWarrantsMember" abstract="true" name="PublicWarrantsPrivatePlacementWarrantsAndWorkingCapitalWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_InitialOrbiMedWarrantMember" abstract="true" name="InitialOrbiMedWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_SubsequentOrbiMedWarrantsEntityOneMember" abstract="true" name="SubsequentOrbiMedWarrantsEntityOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_SubsequentOrbiMedWarrantsEntityTwoMember" abstract="true" name="SubsequentOrbiMedWarrantsEntityTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_SubsequentOrbiMedWarrantsMember" abstract="true" name="SubsequentOrbiMedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_LoanFacilityInitialCommitmentAmountMember" abstract="true" name="LoanFacilityInitialCommitmentAmountMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightRedemptionPrice" abstract="false" name="ClassOfWarrantOrRightRedemptionPrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightConversionDaysNotice" abstract="false" name="ClassOfWarrantOrRightConversionDaysNotice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightConversionStockPriceThreshold" abstract="false" name="ClassOfWarrantOrRightConversionStockPriceThreshold" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightConversionTermsThresholdTradingDays" abstract="false" name="ClassOfWarrantOrRightConversionTermsThresholdTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightConversionTermsThresholdConsecutiveTradingDays" abstract="false" name="ClassOfWarrantOrRightConversionTermsThresholdConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightConversionTermsBusinessDaysRedemptionNoticePeriod" abstract="false" name="ClassOfWarrantOrRightConversionTermsBusinessDaysRedemptionNoticePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightThresholdNumberOfDaysForWarrantsToBeTransferable" abstract="false" name="ClassOfWarrantOrRightThresholdNumberOfDaysForWarrantsToBeTransferable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightWarrantsExchanged" abstract="false" name="ClassOfWarrantOrRightWarrantsExchanged" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightPercentageOfWarrantsTenderAgreement" abstract="false" name="ClassOfWarrantOrRightPercentageOfWarrantsTenderAgreement" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightWarrantsIssuedDelayedDrawCommitmentAmountPercentage" abstract="false" name="ClassOfWarrantOrRightWarrantsIssuedDelayedDrawCommitmentAmountPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_WarrantLiabilityMeasurementInput" abstract="false" name="WarrantLiabilityMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightOwnershipLimitation" abstract="false" name="ClassOfWarrantOrRightOwnershipLimitation" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightRollForward" abstract="true" name="ClassOfWarrantOrRightRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightWarrantsExercised" abstract="false" name="ClassOfWarrantOrRightWarrantsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightSharesIssuedDuringPeriod" abstract="false" name="ClassOfWarrantOrRightSharesIssuedDuringPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightConversionAndRetirementsOfConvertibleSecurities" abstract="false" name="ClassOfWarrantOrRightConversionAndRetirementsOfConvertibleSecurities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseChangeInFairValueOfContingentEarnoutLiabilityAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseChangeInFairValueOfContingentEarnoutLiabilityAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseChangeInFairValueOfSEPAWarrantAndRevenueBaseRedemptionLiabilitiesAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseChangeInFairValueOfSEPAWarrantAndRevenueBaseRedemptionLiabilitiesAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseChangeInFairValueOfContingentEarnoutLiabilityPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseChangeInFairValueOfContingentEarnoutLiabilityPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tlsi_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseChangeInFairValueOfSEPAWarrantAndRevenueBaseRedemptionLiabilitiesPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseChangeInFairValueOfSEPAWarrantAndRevenueBaseRedemptionLiabilitiesPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tlsi_DeferredTaxAssetsFixedAssetsAndIntangibles" abstract="false" name="DeferredTaxAssetsFixedAssetsAndIntangibles" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_DeferredTaxAssetsLeaseAccounting" abstract="false" name="DeferredTaxAssetsLeaseAccounting" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_DeferredTaxAssetsBeforeValuationAllowance" abstract="false" name="DeferredTaxAssetsBeforeValuationAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_ValuationAllowancePercentageOfDeferredTaxAssets" abstract="false" name="ValuationAllowancePercentageOfDeferredTaxAssets" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tlsi_CommercialMilestoneTypeAxis" abstract="true" name="CommercialMilestoneTypeAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_CommercialMilestoneTypeDomain" abstract="true" name="CommercialMilestoneTypeDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_CommercialMilestoneMember" abstract="true" name="CommercialMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_AssetAcquisitionNumberOfUpfrontPayment" abstract="false" name="AssetAcquisitionNumberOfUpfrontPayment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_AssetAcquisitionNumberOfCommercialMilestones" abstract="false" name="AssetAcquisitionNumberOfCommercialMilestones" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_AssetAcquisitionMaximumMilestoneAmount" abstract="false" name="AssetAcquisitionMaximumMilestoneAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_AssetAcquisitionRoyaltyPercentageUnderThresholdAmount" abstract="false" name="AssetAcquisitionRoyaltyPercentageUnderThresholdAmount" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_AssetAcquisitionRoyaltiesSalesThresholdAmount" abstract="false" name="AssetAcquisitionRoyaltiesSalesThresholdAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_AssetAcquisitionRoyaltyPercentageOverThresholdAmount" abstract="false" name="AssetAcquisitionRoyaltyPercentageOverThresholdAmount" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_MeasurementInputExpectedDrawsMember" abstract="true" name="MeasurementInputExpectedDrawsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_CommonStockSharePricePercentageOfAverageDailyVolume" abstract="false" name="CommonStockSharePricePercentageOfAverageDailyVolume" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_CommonStockSharePriceAverageDailyVolumeNumberOfTradingDays" abstract="false" name="CommonStockSharePriceAverageDailyVolumeNumberOfTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_StandbyEquityPurchaseAgreementMaximumAmountOfSharesAuthorized" abstract="false" name="StandbyEquityPurchaseAgreementMaximumAmountOfSharesAuthorized" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_SharePriceAsPercentageOfMarketPriceCommencingOnAdvanceNoticeDate" abstract="false" name="SharePriceAsPercentageOfMarketPriceCommencingOnAdvanceNoticeDate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_SharePriceAsPercentageOfMarketPriceWithAdvanceNoticeOptionTwo" abstract="false" name="SharePriceAsPercentageOfMarketPriceWithAdvanceNoticeOptionTwo" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_CommonStockSharePriceMarketPriceNumberOfConsecutiveTradingDays" abstract="false" name="CommonStockSharePriceMarketPriceNumberOfConsecutiveTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_PurchaseAgreementOwnershipLimitation" abstract="false" name="PurchaseAgreementOwnershipLimitation" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_CommonStockSharesAuthorizedStandbyEquityPurchaseAgreement" abstract="false" name="CommonStockSharesAuthorizedStandbyEquityPurchaseAgreement" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_StandbyEquityPurchaseAgreementMaximumAllowablePercentageOfOutstandingCommonStock" abstract="false" name="StandbyEquityPurchaseAgreementMaximumAllowablePercentageOfOutstandingCommonStock" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_MeasurementInputExpectedProbablyOfDrawsMember" abstract="true" name="MeasurementInputExpectedProbablyOfDrawsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_LoanFacilityMember" abstract="true" name="LoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_LoanFacilityJune302025Member" abstract="true" name="LoanFacilityJune302025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_LoanFacilityDecember312025Member" abstract="true" name="LoanFacilityDecember312025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_LineOfCreditFacilityProductRevenueBaseMinimumThresholdAmount" abstract="false" name="LineOfCreditFacilityProductRevenueBaseMinimumThresholdAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_DebtInstrumentDebtDefaultRate" abstract="false" name="DebtInstrumentDebtDefaultRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tlsi_DebtInstrumentCovenantsMinimumLiquidityCashRequirement" abstract="false" name="DebtInstrumentCovenantsMinimumLiquidityCashRequirement" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_DebtInstrumentMinimumVariableRateSOFRFloor" abstract="false" name="DebtInstrumentMinimumVariableRateSOFRFloor" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_DebtInstrumentPaidInKindInterestTerm" abstract="false" name="DebtInstrumentPaidInKindInterestTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_DebtInstrumentPaidInKindInterestPercentage" abstract="false" name="DebtInstrumentPaidInKindInterestPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tlsi_LineOfCreditFacilityExitFeePercentage" abstract="false" name="LineOfCreditFacilityExitFeePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_RevenueBaseRedemptionFeaturePeriodAxis" abstract="true" name="RevenueBaseRedemptionFeaturePeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_RevenueBaseRedemptionFeaturePeriodDomain" abstract="true" name="RevenueBaseRedemptionFeaturePeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_RevenueBaseRedemptionFeaturePeriodFiveMember" abstract="true" name="RevenueBaseRedemptionFeaturePeriodFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_RevenueBaseRedemptionFeaturePeriodSixMember" abstract="true" name="RevenueBaseRedemptionFeaturePeriodSixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_RevenueBaseRedemptionFeaturePeriodSevenAndThereafterMember" abstract="true" name="RevenueBaseRedemptionFeaturePeriodSevenAndThereafterMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PrepaymentPremiumRatePeriodAxis" abstract="true" name="PrepaymentPremiumRatePeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_PrepaymentPremiumRatePeriodDomain" abstract="true" name="PrepaymentPremiumRatePeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PrepaymentPremiumRatePeriodOneMember" abstract="true" name="PrepaymentPremiumRatePeriodOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PrepaymentPremiumRatePeriodTwoMember" abstract="true" name="PrepaymentPremiumRatePeriodTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PrepaymentPremiumRatePeriodThreeMember" abstract="true" name="PrepaymentPremiumRatePeriodThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PrepaymentPremiumRatePeriodFourMember" abstract="true" name="PrepaymentPremiumRatePeriodFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PrepaymentPremiumRatePeriodFiveMember" abstract="true" name="PrepaymentPremiumRatePeriodFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_DebtInstrumentPrepaymentPremiumRate" abstract="false" name="DebtInstrumentPrepaymentPremiumRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_RevenueBaseRedemptionFeatureAmount" abstract="false" name="RevenueBaseRedemptionFeatureAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_WarrantLiability" abstract="false" name="WarrantLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_DebtInstrumentActivityRollForward" abstract="true" name="DebtInstrumentActivityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_SeriesAConvertiblePreferredStockMember" abstract="true" name="SeriesAConvertiblePreferredStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PreferredStockConvertedToCommonStockMember" abstract="true" name="PreferredStockConvertedToCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PreferredStockIssuedPricePerShare" abstract="false" name="PreferredStockIssuedPricePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tlsi_PreferredStockDividendsUndeclaredCumulativeDividends" abstract="false" name="PreferredStockDividendsUndeclaredCumulativeDividends" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_PreferredStockDividendsUndeclaredActualDividends" abstract="false" name="PreferredStockDividendsUndeclaredActualDividends" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_PreferredStockPercentageOfOutstandingStockTendered" abstract="false" name="PreferredStockPercentageOfOutstandingStockTendered" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_A2023PlanMember" abstract="true" name="A2023PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_A2009PlanMember" abstract="true" name="A2009PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_RestrictedStockUnitsRSUsAndPerformanceShareUnitsPSUsMember" abstract="true" name="RestrictedStockUnitsRSUsAndPerformanceShareUnitsPSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePerYearNumberOfYears" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePerYearNumberOfYears" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardIncreaseAsAPercentOfFullyDilutedSharesInPreviousYear" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardIncreaseAsAPercentOfFullyDilutedSharesInPreviousYear" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePercentageOfTotalShares" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePercentageOfTotalShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePercentageOfInitialShareReserve" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAutomaticIncreasePercentageOfInitialShareReserve" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_CommonStockPeriodIncreaseDecreaseInCapitalSharesReservedForFutureIssuance" abstract="false" name="CommonStockPeriodIncreaseDecreaseInCapitalSharesReservedForFutureIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_StockOptionsAndRestrictedStockUnitsMember" abstract="true" name="StockOptionsAndRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_NumberOfEquityIncentivePlans" abstract="false" name="NumberOfEquityIncentivePlans" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualLifeAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualLifeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_RestrictedStockUnitsAndPerformanceSharesMember" abstract="true" name="RestrictedStockUnitsAndPerformanceSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsReleasedInPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsReleasedInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsReleasedWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsReleasedWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tlsi_CommonStockWarrantMember" abstract="true" name="CommonStockWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_StandbyEquityPurchaseAgreementSEPAMember" abstract="true" name="StandbyEquityPurchaseAgreementSEPAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_WestminsterFacilityMember" abstract="true" name="WestminsterFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_LesseeNumberOfOperatingLeases" abstract="false" name="LesseeNumberOfOperatingLeases" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_LesseeNumberOfFinanceLeases" abstract="false" name="LesseeNumberOfFinanceLeases" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_LesseeOperatingLeaseNumberOfRenewalOptionsExercised" abstract="false" name="LesseeOperatingLeaseNumberOfRenewalOptionsExercised" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_LesseeOperatingLeaseNumberOfRenewalOptions" abstract="false" name="LesseeOperatingLeaseNumberOfRenewalOptions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_OperatingLeaseAssetsAndLiabilitiesLesseeAbstract" abstract="true" name="OperatingLeaseAssetsAndLiabilitiesLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_FinanceLeaseAssetsAndLiabilitiesLesseeAbstract" abstract="true" name="FinanceLeaseAssetsAndLiabilitiesLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_FinanceLeaseCost" abstract="false" name="FinanceLeaseCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_RetirementPlanContributionAmountAxis" abstract="true" name="RetirementPlanContributionAmountAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_RetirementPlanContributionAmountDomain" abstract="true" name="RetirementPlanContributionAmountDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_A3EmployeeContributionMember" abstract="true" name="A3EmployeeContributionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_EmployeeContributionBetween3And4Member" abstract="true" name="EmployeeContributionBetween3And4Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_EmployeeContributionBetween4And5Member" abstract="true" name="EmployeeContributionBetween4And5Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_DefinedContributionPlanEmployerMatchingContributionPercentOfEmployeesGrossPayRateOne" abstract="false" name="DefinedContributionPlanEmployerMatchingContributionPercentOfEmployeesGrossPayRateOne" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_DefinedContributionPlanEmployerMatchingContributionPercentOfEmployeesGrossPayRateTwo" abstract="false" name="DefinedContributionPlanEmployerMatchingContributionPercentOfEmployeesGrossPayRateTwo" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_DefinedContributionPlanEmployerMatchingContributionPercentOfEmployeesGrossPayRateThree" abstract="false" name="DefinedContributionPlanEmployerMatchingContributionPercentOfEmployeesGrossPayRateThree" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_UnderwritingAgreementMember" abstract="true" name="UnderwritingAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PublicOfferingMember" abstract="true" name="PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_SaleOfStockOverAllotmentOptionPeriod" abstract="false" name="SaleOfStockOverAllotmentOptionPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
